Targeted silencing of miRNA-132-3p expression rescues disuse osteopenia by promoting mesenchymal stem cell osteogenic differentiation and osteogenesis in mice

BACKGROUND: Skeletal unloading can induce severe disuse osteopenia that often occurs in spaceflight astronauts or in patients subjected to prolonged bed-rest or immobility. Previously, we revealed a mechano-sensitive factor, miRNA-132-3p, that is closely related to the osteoblast function. The aim o...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Hu, Zebing, Zhang, Lijun, Wang, Han, Wang, Yixuan, Tan, Yingjun, Dang, Lei, Wang, Ke, Sun, Zhongyang, Li, Gaozhi, Cao, Xinsheng, Zhang, Shu, Shi, Fei, Zhang, Ge
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020585/
https://ncbi.nlm.nih.gov/pubmed/32054528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-1581-6
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