Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone–Atomoxetine Interaction

There is a paucity of clinical trials for the treatment of pediatric insomnia. This study was designed to predict the doses of trazodone to guide dosing in a clinical trial for pediatric insomnia using physiologically‐based pharmacokinetic (PBPK) modeling. Data on the pharmacokinetics of trazodone i...

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Bibliografiske detaljer
Udgivet i:CPT Pharmacometrics Syst Pharmacol
Main Authors: Oggianu, Laura, Ke, Alice B., Chetty, Manoranjenni, Picollo, Rossella, Petrucci, Vanessa, Calisti, Fabrizio, Garofolo, Fabio, Tongiani, Serena
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020267/
https://ncbi.nlm.nih.gov/pubmed/31808613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12480
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