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Low-Dose and Long-Term Olaparib Treatment Sensitizes MDA-MB-231 and SUM1315 Triple-Negative Breast Cancers Spheroids to Fractioned Radiotherapy

The Triple-Negative Breast Cancer subtype (TNBC) is particularly aggressive and heterogeneous. Thus, Poly-ADP-Ribose Polymerase inhibitors were developed to improve the prognosis of patients and treatment protocols are still being evaluated. In this context, we modelized the efficacy of Olaparib (i....

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Detalhes bibliográficos
Publicado no:J Clin Med
Main Authors: Dubois, Clémence, Martin, Fanny, Hassel, Chervin, Magnier, Florian, Daumar, Pierre, Aubel, Corinne, Guerder, Sylvie, Mounetou, Emmanuelle, Penault-Lorca, Frédérique, Bamdad, Mahchid
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019977/
https://ncbi.nlm.nih.gov/pubmed/31888054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9010064
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