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Opposite Charge Movements Within the Photoactive Site Modulate Two-Step Channel Closing in GtACR1

Guillardia theta anion channelrhodopsin 1 is a light-gated anion channel widely used as an optogenetic inhibitory tool. Our recently published crystal structure of its dark (closed) state revealed that the photoactive retinylidene chromophore is located midmembrane in a full-length intramolecular tu...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Sineshchekov, Oleg A., Govorunova, Elena G., Li, Hai, Wang, Xin, Spudich, John L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018983/
https://ncbi.nlm.nih.gov/pubmed/31676131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.10.009
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