Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation

Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids interact with each other in the mammalian plasma membranes, forming dynamic microdomains. How their interaction starts in the cells has been unclear. Here, based on a genome-wide CRISPR-Cas9 genetic screen for genes required...

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Vydáno v:Nat Commun
Hlavní autoři: Wang, Yicheng, Maeda, Yusuke, Liu, Yi-Shi, Takada, Yoko, Ninomiya, Akinori, Hirata, Tetsuya, Fujita, Morihisa, Murakami, Yoshiko, Kinoshita, Taroh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018848/
https://ncbi.nlm.nih.gov/pubmed/32054864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14678-2
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