Hydrodynamics-based liver transfection achieves gene silencing of CB1 using short hairpin RNA plasmid in cirrhotic rats

BACKGROUND: There is a correlation between the endocannabinoid system and hepatic fibrosis based on the activation of CB1 and CB2 receptors; where CB1 has profibrogenic effects. Gene therapy with a plasmid carrying a shRNA for CB1 delivered by hydrodynamic injection has the advantage of hepatic trop...

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Publicat a:PLoS One
Autors principals: Díaz-Rivera, Adriana, Meza-Ríos, Alejandra, Chagoya de Sánchez, Victoria, Velasco-Loyden, Gabriela, García-Benavides, Leonel, Jave-Suarez, Luis F., Monroy-Ramirez, Hugo Christian, Santos-García, Arturo, Armendáriz-Borunda, Juan, Sandoval-Rodríguez, Ana
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018086/
https://ncbi.nlm.nih.gov/pubmed/32053633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228729
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