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Preclinical Pharmacokinetics of Complement C5a Receptor Antagonists PMX53 and PMX205 in Mice
[Image: see text] The cyclic hexapeptides PMX53 and PMX205 are potent noncompetitive inhibitors of complement C5a receptor 1 (C5aR1). They are widely utilized to study the role of C5aR1 in mouse models, including central nervous system (CNS) disease, and are dosed through a variety of routes of admi...
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| Publicado en: | ACS Omega |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7017397/ https://ncbi.nlm.nih.gov/pubmed/32064396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b03735 |
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