LRP1-Mediated AggLDL Endocytosis Promotes Cholesteryl Ester Accumulation and Impairs Insulin Response in HL-1 Cells

The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization is mediated by low-density lipoprotein receptor-related protein-1 (LRP1)...

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Vydáno v:Cells
Hlavní autoři: Actis Dato, Virginia, Benitez-Amaro, Aleyda, de Gonzalo-Calvo, David, Vazquez, Maximiliano, Bonacci, Gustavo, Llorente-Cortés, Vicenta, Chiabrando, Gustavo Alberto
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016900/
https://ncbi.nlm.nih.gov/pubmed/31936892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9010182
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