Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates

Cell-derived extracellular matrix (ECM) provides a niche to promote osteogenic differentiation, cell adhesion, survival, and trophic factor secretion. To determine whether osteogenic preconditioning would improve the bone-forming potential of unfractionated bone marrow aspirate (BMA), we perfused ce...

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Udgivet i:Sci Adv
Main Authors: Harvestine, J. N., Gonzalez-Fernandez, T., Sebastian, A., Hum, N. R., Genetos, D. C., Loots, G. G., Leach, J. K.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015678/
https://ncbi.nlm.nih.gov/pubmed/32095526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay2387
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