Screening ToxCast™ for Chemicals That Affect Cholesterol Biosynthesis: Studies in Cell Culture and Human Induced Pluripotent Stem Cell–Derived Neuroprogenitors

BACKGROUND: Changes in cholesterol metabolism are common hallmarks of neurodevelopmental pathologies. A diverse array of genetic disorders of cholesterol metabolism support this claim as do multiple lines of research that demonstrate chemical inhibition of cholesterol biosynthesis compromises neurod...

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Detalhes bibliográficos
Publicado no:Environ Health Perspect
Main Authors: Wages, Phillip A., Joshi, Piyush, Tallman, Keri A., Kim, Hye-Young H., Bowman, Aaron B., Porter, Ned A.
Formato: Artigo
Idioma:Inglês
Publicado em: Environmental Health Perspectives 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015578/
https://ncbi.nlm.nih.gov/pubmed/31985273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP5053
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