Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone microtumors

PURPOSE: Targeted alpha therapy (TAT) is a promising treatment for micrometastatic and minimal residual cancer. We evaluated systemic α-radioimmunotherapy (α-RIT) of metastatic castration-resistant prostate cancer (mCRPC) using the α-particle emitter (211)At-labeled to the anti-PSCA A11 minibody. A1...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Bäck, Tom A., Jennbacken, Karin, Hagberg Thulin, Malin, Lindegren, Sture, Jensen, Holger, Olafsen, Tove, Yazaki, Paul J., Palm, Stig, Albertsson, Per, Damber, Jan-Erik, Wu, Anna M., Welén, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013029/
https://ncbi.nlm.nih.gov/pubmed/32048062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-020-0600-z
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