Notochord vacuoles absorb compressive bone growth during zebrafish spine formation

The vertebral column or spine assembles around the notochord rod which contains a core made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to spine kinking. Here, we identified a mutation in the ki...

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Pubblicato in:eLife
Autori principali: Bagwell, Jennifer, Norman, James, Ellis, Kathryn, Peskin, Brianna, Hwang, James, Ge, Xiaoyan, Nguyen, Stacy V, McMenamin, Sarah K, Stainier, Didier YR, Bagnat, Michel
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012607/
https://ncbi.nlm.nih.gov/pubmed/31995030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51221
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