Anti-PLA2R1 Antibodies Containing Sera Induce In Vitro Cytotoxicity Mediated by Complement Activation

The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic membranous nephropathy (MN). However, the pathogenic role of anti-PLA2R1 autoantibodies is unclear. Our aim was to evaluate the in vitro cytotoxicity of anti-PLA2R1 antibodies mediated by complement. Forty-eight patients w...

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Pubblicato in:J Immunol Res
Autori principali: Lateb, Maël, Ouahmi, Hajar, Payré, Christine, Brglez, Vesna, Zorzi, Kevin, Dolla, Guillaume, Zaidan, Mohamad, Boyer-Suavet, Sonia, Knebelmann, Bertrand, Crépin, Thomas, Courivaud, Cécile, Jourde-Chiche, Noémie, Esnault, Vincent, Lambeau, Gérard, Seitz-Polski, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012209/
https://ncbi.nlm.nih.gov/pubmed/32083137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1324804
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