Production of an anti-angiogenic factor sFLT1 is suppressed via promoter hypermethylation of FLT1 gene in choriocarcinoma cells

BACKGROUND: Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly angiogenic and metastatic. However, the molecular mechanism underlying angiogenes...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Sasagawa, Tadashi, Jinno-Oue, Atsushi, Nagamatsu, Takeshi, Morita, Kazuki, Tsuruga, Tetsushi, Mori-Uchino, Mayuyo, Fujii, Tomoyuki, Shibuya, Masabumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011436/
https://ncbi.nlm.nih.gov/pubmed/32041578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-6598-9
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