Enhanced E. coli LF82 Translocation through the Follicle-associated Epithelium in Crohn’s Disease is Dependent on Long Polar Fimbriae and CEACAM6 expression, and Increases Paracellular Permeability

BACKGROUND AND AIMS: Patients with Crohn’s disease [CD] harbour an increased number of adherent-invasive E. coli [AIEC]. The strain LF82, identified in the ileal mucosa of CD patients, has been extensively studied for pathogenic mechanisms. However, understanding of the interaction of LF82 with the...

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Veröffentlicht in:J Crohns Colitis
Hauptverfasser: Keita, Åsa V, Alkaissi, Lina Yakymenko, Holm, Elin B, Heil, Stéphanie D S, Chassaing, Benoit, Darfeuille-Michaud, Arlette, McKay, Derek M, Söderholm, Johan D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008151/
https://ncbi.nlm.nih.gov/pubmed/31393983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjz144
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