Codon optimized membrane cofactor protein expression in α 1, 3 galactosyltransferase knockout pig cells improve protection against cytotoxicity of monkey serum

In this study, we attempted to upgrade GT(−MCP/−MCP) pig genetically to express MCP at a higher level and additionally thrombomodulin (TBM), which have respective roles as a complement regulatory protein and a coagulation inhibitor. We constructed a dicistronic cassette consisting of codon-optimized...

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Veröffentlicht in:3 Biotech
Hauptverfasser: Lee, Heasun, Hwang, In-sul, Vasamsetti, Bala Murali Krishna, Rallabandi, Harikrishna Reddy, Park, Mi-Ryung, Byun, Sung-June, Yang, Hyeon, Ock, Sun A., Lee, Hwi-Cheul, Woo, Jae-Seok, Hwang, Seongsoo, Oh, Keon Bong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008109/
https://ncbi.nlm.nih.gov/pubmed/32095422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13205-020-2091-z
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