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The IL-4/IL-13 Axis in Skin Fibrosis and Scarring: Mechanistic Concepts and Therapeutic Targets

BACKGROUND: Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. Effective anti-scarring therapeutics remain an unmet...

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Detalhes bibliográficos
Publicado no:Arch Dermatol Res
Main Authors: Nguyen, Julie K., Austin, Evan, Huang, Alisen, Mamalis, Andrew, Jagdeo, Jared
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008089/
https://ncbi.nlm.nih.gov/pubmed/31493000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00403-019-01972-3
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