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Adaptation to chronic acidic extracellular pH elicits a sustained increase in lung cancer cell invasion and metastasis

Acidic extracellular pH (pH(e)) is an important microenvironment for cancer cells. This study assessed whether adaptation to acidic pH(e) enhances the metastatic phenotype of tumor cells. The low metastatic variant of Lewis lung carcinoma (LLCm1) cells were subjected to stepwise acidification, estab...

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Detalles Bibliográficos
Publicado en:Clin Exp Metastasis
Main Authors: Sutoo, Shusaku, Maeda, Toyonobu, Suzuki, Atsuko, Kato, Yasumasa
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007909/
https://ncbi.nlm.nih.gov/pubmed/31489536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-019-09990-1
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