In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

Despite substantial progress in lung cancer immunotherapy, the overall response rate in KRAS-mutant lung adenocarcinoma (ADC) patients remains low. Combining standard immunotherapy with adjuvant approaches that enhance adaptive immune responses—such as epigenetic modulation of anti-tumor immunity—is...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Li, Fei, Huang, Qingyuan, Luster, Troy A., Hu, Hai, Zhang, Hua, Ng, Wai-Lung, Khodadadi-Jamayran, Alireza, Wang, Wei, Chen, Ting, Deng, Jiehui, Ranieri, Michela, Fang, Zhaoyuan, Pyon, Val, Dowling, Catríona M., Bagdatlioglu, Ece, Almonte, Christina, Labbe, Kristen, Silver, Heather, Rabin, Alexandra R., Jani, Kandarp, Tsirigos, Aristotelis, Papagiannakopoulos, Thales, Hammerman, Peter S., Velcheti, Vamsidhar, Freeman, Gordon J., Qi, Jun, Miller, George, Wong, Kwok-Kin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007372/
https://ncbi.nlm.nih.gov/pubmed/31744829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0780
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