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Integrated stress response in hepatitis C promotes Nrf2-related chaperone-mediated autophagy: a novel mechanism for host-microbe survival and HCC development in liver cirrhosis

The molecular mechanism(s) how liver damage during the chronic hepatitis C virus (HCV) infection evolve into cirrhosis and hepatocellular carcinoma (HCC) is unclear. HCV infects hepatocyte, the major cell types in the liver. During infection, large amounts of viral proteins and RNA replication inter...

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Detalhes bibliográficos
Publicado no:Semin Cell Dev Biol
Main Authors: Dash, Srikanta, Aydin, Yucel, Wu, Tong
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007355/
https://ncbi.nlm.nih.gov/pubmed/31386899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2019.07.015
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