The dipeptidyl peptidase-4 inhibitor, linagliptin, improves cognitive impairment in streptozotocin-induced diabetic mice by inhibiting oxidative stress and microglial activation

OBJECTIVE: Accumulating epidemiological studies have demonstrated that diabetes is an important risk factor for dementia. However, the underlying pathological and molecular mechanisms, and effective treatment, have not been fully elucidated. Herein, we investigated the effect of the dipeptidyl pepti...

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Publicado en:PLoS One
Autores principales: Ide, Makoto, Sonoda, Noriyuki, Inoue, Tomoaki, Kimura, Shinichiro, Minami, Yohei, Makimura, Hiroaki, Hayashida, Eiichi, Hyodo, Fuminori, Yamato, Mayumi, Takayanagi, Ryoichi, Inoguchi, Toyoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006898/
https://ncbi.nlm.nih.gov/pubmed/32032367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228750
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