Using Electronic Health Records to Derive Control Arms for Early Phase Single‐Arm Lung Cancer Trials: Proof‐of‐Concept in Randomized Controlled Trials

Oncology drug development increasingly relies on single‐arm clinical trials. External controls (ECs) derived from electronic health record (EHR) databases may provide additional context. Patients from a US‐based oncology EHR database were aligned with patients from randomized controlled trials (RCTs...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Carrigan, Gillis, Whipple, Samuel, Capra, William B., Taylor, Michael D., Brown, Jeffrey S., Lu, Michael, Arnieri, Brandon, Copping, Ryan, Rothman, Kenneth J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006884/
https://ncbi.nlm.nih.gov/pubmed/31350853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1586
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