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Reversible photoswitching of the DNA-binding properties of styrylquinolizinium derivatives through photochromic [2 + 2] cycloaddition and cycloreversion

It was demonstrated that styrylquinolizinium derivatives may be applied as photoswitchable DNA ligands. At lower ligand:DNA ratios (≤1.5), these compounds bind to duplex DNA by intercalation, with binding constants ranging from K(b) = 4.1 × 10(4) M to 2.6 × 10(5) M (four examples), as shown by photo...

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Detalhes bibliográficos
Publicado no:Beilstein J Org Chem
Main Authors: Kölsch, Sarah, Ihmels, Heiko, Mattay, Jochen, Sewald, Norbert, Patrick, Brian O
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006495/
https://ncbi.nlm.nih.gov/pubmed/32082430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.16.13
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