CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide

Multiple myeloma (MM) is a plasma cell malignancy and most patients eventually succumb to the disease. Chimeric antigen receptor (CAR) T cells targeting B-Cell Maturation Antigen (BCMA) on MM cells have shown high-response rates, but limited durability. CD229/LY9 is a cell surface receptor present o...

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Udgivet i:Nat Commun
Main Authors: Radhakrishnan, Sabarinath V., Luetkens, Tim, Scherer, Sandra D., Davis, Patricia, Vander Mause, Erica R., Olson, Michael L., Yousef, Sara, Panse, Jens, Abdiche, Yasmina, Li, K. David, Miles, Rodney R., Matsui, William, Welm, Alana L., Atanackovic, Djordje
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005855/
https://ncbi.nlm.nih.gov/pubmed/32034142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14619-z
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