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Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method
While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precis...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7005789/ https://ncbi.nlm.nih.gov/pubmed/32034220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58877-9 |
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