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Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

Fatty acid and triglyceride synthesis increases greatly in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of various enzymes in lipogenic pathway, including fatty acid synthase and glycerol-3-phosphate acyltransferase. Here, we show that JMJD...

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Detalhes bibliográficos
Publicado no:Nat Commun
Principais autores: Viscarra, Jose A., Wang, Yuhui, Nguyen, Hai P., Choi, Yoon Gi, Sul, Hei Sook
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005700/
https://ncbi.nlm.nih.gov/pubmed/32034158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14617-1
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