A new experimental mouse model of water intoxication with sustained increased intracranial pressure and mild hyponatremia without side effects of antidiuretics

The most used experimental mouse model of hyponatremia and elevated intracranial pressure (ICP) is intraperitoneal injection of water in combination with antidiuretics. This model of water intoxication (WI) results in extreme pathological changes and death within 1 h. To improve preclinical studies...

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Bibliographic Details
Published in:Exp Anim
Main Authors: Bordoni, Luca, Jiménez, Eugenio Gutiérrez, Nielsen, Søren, Østergaard, Leif, Frische, Sebastian
Format: Artigo
Language:Inglês
Published: Japanese Association for Laboratory Animal Science 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004811/
https://ncbi.nlm.nih.gov/pubmed/31534063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.19-0040
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