Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence

Hit‐to‐lead optimization is a critical phase in drug discovery. Herein, we report on the fragment‐based discovery and optimization of 2‐aminopyridine derivatives as a novel lead‐like structure for the treatment of the dangerous opportunistic pathogen Pseudomonas aeruginosa. We pursue an innovative t...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Zender, Michael, Witzgall, Florian, Kiefer, Alexander, Kirsch, Benjamin, Maurer, Christine K., Kany, Andreas M., Xu, Ningna, Schmelz, Stefan, Börger, Carsten, Blankenfeldt, Wulf, Empting, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004148/
https://ncbi.nlm.nih.gov/pubmed/31709767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900621
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