Computer‐Assisted Recombination (CompassR) Teaches us How to Recombine Beneficial Substitutions from Directed Evolution Campaigns

A main remaining challenge in protein engineering is how to recombine beneficial substitutions. Systematic recombination studies show that poorly performing variants are usually obtained after recombination of 3 to 4 beneficial substitutions. This limits researchers in exploiting nature's poten...

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Publicat a:Chemistry
Autors principals: Cui, Haiyang, Cao, Hao, Cai, Haiying, Jaeger, Karl‐Erich, Davari, Mehdi D., Schwaneberg, Ulrich
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Full Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003928/
https://ncbi.nlm.nih.gov/pubmed/31553080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201903994
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