Combining In Vitro Data and Physiologically Based Kinetic Modeling Facilitates Reverse Dosimetry to Define In Vivo Dose–Response Curves for Bixin‐ and Crocetin‐Induced Activation of PPARγ in Humans

SCOPE: It is investigated whether at realistic dietary intake bixin and crocetin could induce peroxisome proliferator‐activated receptor γ (PPARγ)‐mediated gene expression in humans using a combined in vitro–in silico approach. METHODS AND RESULTS: Concentration–response curves obtained from in vitr...

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Detalhes bibliográficos
Publicado no:Mol Nutr Food Res
Main Authors: Suparmi, Suparmi, de Haan, Laura, Spenkelink, Albertus, Louisse, Jochem, Beekmann, Karsten, Rietjens, Ivonne M. C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003908/
https://ncbi.nlm.nih.gov/pubmed/31846197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201900880
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