Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide clinical benefits over chemotherapy for lung cancer patients with EGFR activating mutations. Despite initial clinical responses, long‐term efficacy is not possible because of acquired resistance to these therapies. We...

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Detalhes bibliográficos
Publicado no:FASEB Bioadv
Main Authors: Howell, Mark C., Green, Ryan, Khalil, Roukiah, Foran, Elspeth, Quarni, Waise, Nair, Rajesh, Stevens, Stanley, Grinchuk, Aleksandr, Hanna, Andrew, Mohapatra, Shyam, Mohapatra, Subhra
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003654/
https://ncbi.nlm.nih.gov/pubmed/32123859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2019-00081
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