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The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy
Inducible T cell costimulator (ICOS, cluster of differentiation (CD278)) is an activating costimulatory immune checkpoint expressed on activated T cells. Its ligand, ICOSL is expressed on antigen-presenting cells and somatic cells, including tumour cells in the tumour microenvironment. ICOS and ICOS...
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| Publicado no: | ESMO Open |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMJ Publishing Group
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7003380/ https://ncbi.nlm.nih.gov/pubmed/32516116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/esmoopen-2019-000544 |
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