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The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy

Inducible T cell costimulator (ICOS, cluster of differentiation (CD278)) is an activating costimulatory immune checkpoint expressed on activated T cells. Its ligand, ICOSL is expressed on antigen-presenting cells and somatic cells, including tumour cells in the tumour microenvironment. ICOS and ICOS...

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Detalhes bibliográficos
Publicado no:ESMO Open
Main Authors: Solinas, Cinzia, Gu-Trantien, Chunyan, Willard-Gallo, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003380/
https://ncbi.nlm.nih.gov/pubmed/32516116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/esmoopen-2019-000544
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