Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers

BACKGROUND: Ferroptosis, nonapoptotic cell death mediated by free radical reactions and driven by the oxidative degradation of lipids, is a therapeutic target because of its role in organ damage, including AKI. Ferroptosis-causing radicals that are targeted by ferroptosis suppressors have not been u...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Mishima, Eikan, Sato, Emiko, Ito, Junya, Yamada, Ken-ichi, Suzuki, Chitose, Oikawa, Yoshitsugu, Matsuhashi, Tetsuro, Kikuchi, Koichi, Toyohara, Takafumi, Suzuki, Takehiro, Ito, Sadayoshi, Nakagawa, Kiyotaka, Abe, Takaaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2020
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003311/
https://ncbi.nlm.nih.gov/pubmed/31767624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019060570
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