Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GN

BACKGROUND: Myeloperoxidase released after neutrophil and monocyte activation can generate reactive oxygen species, leading to host tissue damage. Extracellular glomerular myeloperoxidase deposition, seen in ANCA-associated vasculitis, may enhance crescentic GN through antigen-specific T and B cell...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Antonelou, Marilina, Michaëlsson, Erik, Evans, Rhys D.R., Wang, Chun Jing, Henderson, Scott R., Walker, Lucy S.K., Unwin, Robert John, Salama, Alan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2020
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003306/
https://ncbi.nlm.nih.gov/pubmed/31879336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019060618
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