Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway

Inhalation of conidia of the opportunistic mold Aspergillus fumigatus by immunocompromised hosts can lead to invasive pulmonary disease. Inhaled conidia that escape immune defenses germinate to form filamentous hyphae that invade lung tissues. Conidiation rarely occurs during invasive infection of t...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Stewart, James I. P., Fava, Vinicius M., Kerkaert, Joshua D., Subramanian, Adithya S., Gravelat, Fabrice N., Lehoux, Melanie, Howell, P. Lynne, Cramer, Robert A., Sheppard, Donald C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002347/
https://ncbi.nlm.nih.gov/pubmed/32019801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03202-19
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