A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90

Genome-wide association studies (GWASs) implicate 16q22.1 locus in risk for colorectal cancer (CRC). However, the underlying oncogenic mechanisms remain unknown. Here, through comprehensive filtration, we prioritized rs7198799, a common SNP in the second intron of the CDH1, as the putative causal va...

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Publicat a:Oncogene
Autors principals: Yu, Chen-Yang, Han, Ji-Xuan, Zhang, Junfang, Jiang, Penglei, Shen, Chaoqin, Guo, Fangfang, Tang, Jiayin, Yan, Tingting, Tian, Xianglong, Zhu, Xiaoqiang, Ma, Dan, Hu, Ye, Xie, Yuanhong, Du, Wan, Zhong, Ming, Chen, Jinxian, Liu, Qiang, Sun, Danfeng, Chen, Yingxuan, Zou, Weiping, Hong, Jie, Chen, Haoyan, Fang, Jing-Yuan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002302/
https://ncbi.nlm.nih.gov/pubmed/31641208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1055-4
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