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Visualizing locus-specific sister chromatid exchange reveals differential patterns of replication stress-induced fragile site breakage
Chromosomal fragile sites are genomic loci sensitive to replication stress which accumulate high levels of DNA damage, and are frequently mutated in cancers. Fragile site damage is thought to arise from the aberrant repair of spontaneous replication stress, however successful fragile site repair can...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7002298/ https://ncbi.nlm.nih.gov/pubmed/31636383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1054-5 |
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