A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward

Nociceptin and its receptor are widely distributed throughout the brain in regions associated with reward behavior, yet how and when they act is unknown. Here we dissected the role of a nociceptin peptide circuit in reward seeking. We generated a prepronociceptin (Pnoc)-Cre mouse line that revealed...

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Pubblicato in:Cell
Autori principali: Parker, Kyle E., Pedersen, Christian E., Gomez, Adrian M., Spangler, Skylar M., Walicki, Marie C., Feng, Shelley Y., Stewart, Sarah L., Otis, James M., Al-Hasani, Ream, McCall, Jordan G., Sakers, Kristina, Bhatti, Dionnet L., Copits, Bryan A., Gereau, Robert W., Jhou, Thomas, Kash, Thomas J., Dougherty, Joseph D., Stuber, Garret D., Bruchas, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001890/
https://ncbi.nlm.nih.gov/pubmed/31348890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.06.034
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