HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53‐dependent mitochondrial apoptosis

Apoptotic signalling by p53 occurs at both transcriptional and non‐transcriptional levels, as p53 may act as a direct apoptogenic stimulus via activation of the intrinsic mitochondrial pathway. HOPS is a highly conserved, ubiquitously expressed shuttling protein with an ubiquitin‐like domain. We gen...

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Publicado en:EMBO Rep
Autores principales: Castelli, Marilena, Piobbico, Danilo, Chiacchiaretta, Martina, Brunacci, Cinzia, Pieroni, Stefania, Bartoli, Daniela, Gargaro, Marco, Fallarino, Francesca, Puccetti, Paolo, Soddu, Silvia, Della‐Fazia, Maria Agnese, Servillo, Giuseppe
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001502/
https://ncbi.nlm.nih.gov/pubmed/31867855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948073
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