Naturally Occurring and Engineered Alphaviruses Sensitive to Double-Stranded-RNA-Activated Protein Kinase Show Restricted Translation in Mammalian Cells, Increased Sensitivity to Interferon, and Marked Oncotropism

Alphaviruses are insect-borne viruses that alternate between replication in mosquitoes and vertebrate species. Adaptation of some alphaviruses to vertebrate hosts has involved the acquisition of an RNA structure (downstream loop [DLP]) in viral subgenomic mRNAs that confers translational resistance...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Toribio, René, Díaz-López, Irene, Berlanga, Juan José, Molina-Jiménez, Francisca, Majano, Pedro, Ventoso, Iván
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Cellular Response to Infection
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000984/
https://ncbi.nlm.nih.gov/pubmed/31723025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01630-19
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