Inferring fetal fractions from read heterozygosity empowers the noninvasive prenatal screening

PURPOSE: Fetal fraction (FF) is the percent of cell-free DNA (cfDNA) in the mother’s peripheral blood that is of fetal origin, which plays a pivotal role in noninvasive prenatal screening (NIPS). We present a method that can reliably estimate FFs by examining autosome single-nucleotide polymorphisms...

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Bibliografiske detaljer
Udgivet i:Genet Med
Main Authors: Dang, Minghao, Xu, Hanli, Zhang, Jingbo, Wang, Weiwei, Bai, Ling, Fang, Nan, Liang, Lin, Zhang, Junrong, Liu, Feiran, Wu, Qixi, Wang, Shaowei, Guan, Yongtao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group US 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000331/
https://ncbi.nlm.nih.gov/pubmed/31467446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-019-0636-5
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