A knock-in mutation at Cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 release

TRIM72 is a membrane repair protein that protects against ischemia reperfusion (I/R) injury. We previously identified Cys(144) (C144) on TRIM72 as a site of S-nitrosylation. To study the importance of C144, we generated a knock-in mouse with C144 mutated to a serine (TRIM72 C144S). We subjected ex v...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Fillmore, Natasha, Casin, Kevin M., Sinha, Prithvi, Sun, Junhui, Ma, Hanley, Boylston, Jennifer, Noguchi, Audrey, Liu, Chengyu, Wang, Nadan, Zhou, Guangshuo, Kohr, Mark J., Murphy, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000244/
https://ncbi.nlm.nih.gov/pubmed/31536744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.09.008
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