Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway

Biosynthetic pathways containing multiple core enzymes have potential to produce structurally complex natural products. Here we mined a fungal gene cluster that contains two predicted terpene cyclases (TCs) and a nonribosomal peptide synthetase (NRPS). We showed the flv pathway produces flavunoidine...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Yee, Danielle A., Kakule, Thomas B., Cheng, Wei, Chen, Mengbin, Chong, Christine T. Y., Hai, Yang, Hang, Leibniz F., Hung, Yiu-Sun, Liu, Nicholas, Ohashi, Masao, Okorafor, Ikechukwu C., Song, Yongxiang, Tang, Mancheng, Zhang, Zhuang, Tang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000236/
https://ncbi.nlm.nih.gov/pubmed/31885262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b13046
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