Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation to replace the lost myocardium. To identify which processes occur in prolife...

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Veröffentlicht in:eLife
Hauptverfasser: Honkoop, Hessel, de Bakker, Dennis EM, Aharonov, Alla, Kruse, Fabian, Shakked, Avraham, Nguyen, Phong D, de Heus, Cecilia, Garric, Laurence, Muraro, Mauro J, Shoffner, Adam, Tessadori, Federico, Peterson, Joshua Craiger, Noort, Wendy, Bertozzi, Alberto, Weidinger, Gilbert, Posthuma, George, Grün, Dominic, van der Laarse, Willem J, Klumperman, Judith, Jaspers, Richard T, Poss, Kenneth D, van Oudenaarden, Alexander, Tzahor, Eldad, Bakkers, Jeroen
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000220/
https://ncbi.nlm.nih.gov/pubmed/31868166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50163
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