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Direct Carbon Isotope Exchange Through Decarboxylative Carboxylation

A two-step degradation-reconstruction approach to the carbon-14 radiolabeling of alkyl carboxylic acids is presented. Simple activation via redox-active ester formation was followed by nickel-mediated decarboxylative carboxylation to afford a range of complex compounds with ample isotopic incorporat...

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Publicat a:J Am Chem Soc
Autors principals: Kingston, Cian, Wallace, Michael A., Allentoff, Alban J., deGruyter, Justine N., Chen, Jason S., Gong, Sharon X., Bonacorsi, Samuel, Baran, Phil S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000106/
https://ncbi.nlm.nih.gov/pubmed/30605319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b12035
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