Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation

Particulate matter (PM) is able to induce airway epithelial injury, while the detailed mechanisms remain unclear. Here we demonstrated that PM exposure inactivated MTOR (mechanistic target of rapamycin kinase), enhanced macroautophagy/autophagy, and impaired lysosomal activity in HBE (human bronchia...

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Bibliografiska uppgifter
I publikationen:Autophagy
Huvudupphovsmän: Wu, Yin-Fang, Li, Zhou-Yang, Dong, Ling-Ling, Li, Wei-Jie, Wu, Yan-Ping, Wang, Jing, Chen, Hai-Pin, Liu, Hui-Wen, Li, Miao, Jin, Ci-Liang, Huang, Hua-Qiong, Ying, Song-Min, Li, Wen, Shen, Hua-Hao, Chen, Zhi-Hua
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2019
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999647/
https://ncbi.nlm.nih.gov/pubmed/31203721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1628536
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