Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits

Macroautophagy/autophagy is generally regarded as a cytoprotective mechanism, and it remains a matter of controversy whether autophagy can cause cell death in mammals. Here, we show that chronic restraint stress suppresses adult hippocampal neurogenesis in mice by inducing autophagic cell death (ACD...

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Veröffentlicht in:Autophagy
Hauptverfasser: Jung, Seonghee, Choe, Seongwon, Woo, Hanwoong, Jeong, Hyeonjeong, An, Hyun-Kyu, Moon, Hyewon, Ryu, Hye Young, Yeo, Bo Kyoung, Lee, Ye Won, Choi, Hyosun, Mun, Ji Young, Sun, Woong, Choe, Han Kyoung, Kim, Eun-Kyoung, Yu, Seong-Woon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999625/
https://ncbi.nlm.nih.gov/pubmed/31234698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1630222
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