A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models

BACKGROUND: TLRs are some of the actively pursued drug-targets in immune disorders. Owing to a recent surge in the cognizance of TLR structural biology and signalling pathways, numerous therapeutic modulators, ranging from low-molecular-weight organic compounds to polypeptides and nucleic acid agent...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Achek, Asma, Kwon, Hyuk-Kwon, Patra, Mahesh Chandra, Shah, Masaud, Hong, Riwon, Lee, Wang Hee, Baek, Wook-Young, Choi, Yang Seon, Kim, Gi-Young, Pham, Thuong L.H., Suh, Chang-Hee, Kim, Wook, Hahm, Dae-Hyun, Choi, Sangdun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997517/
https://ncbi.nlm.nih.gov/pubmed/32014819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102645
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