Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome

BACKGROUND: The ovulatory dysfunction mechanisms underlying polycystic ovary syndrome (PCOS) are not completely understood. There is no effective therapy for PCOS so far. METHODS: We measured the expression of four and a half LIM domain 2 (FHL2) and other related-genes in human granulosa cells (hGCs...

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Dades bibliogràfiques
Publicat a:EBioMedicine
Autors principals: Zhou, Ruiqiong, Li, Shang, Liu, Jiansheng, Wu, Hasiximuke, Yao, Guangxin, Sun, Yun, Chen, Zi-Jiang, Li, Weiping, Du, Yanzhi
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Research paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997507/
https://ncbi.nlm.nih.gov/pubmed/32028069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102635
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