Human UDP-galactose 4′-epimerase (GALE) is required for cell-surface glycome structure and function

Glycan biosynthesis relies on nucleotide sugars (NSs), abundant metabolites that serve as monosaccharide donors for glycosyltransferases. In vivo, signal-dependent fluctuations in NS levels are required to maintain normal cell physiology and are dysregulated in disease. However, how mammalian cells...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Broussard, Alex, Florwick, Alyssa, Desbiens, Chelsea, Nischan, Nicole, Robertson, Corrina, Guan, Ziqiang, Kohler, Jennifer J., Wells, Lance, Boyce, Michael
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996900/
https://ncbi.nlm.nih.gov/pubmed/31819007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009271
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